The Nobel Prize in Physiology or Medicine for 2006 jointly to Andrew Fire and Craig Mello
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چکیده
An adult human being has about 100 000 billion cells. The nucleus of each cell carries all our genetic material: a total of two meters of DNA containing some 30 000 genes. When genes are expressed (activated), genetic information is copied from DNA to messenger molecules, messenger RNA (mRNA), which then orchestrate formation of proteins. Proteins are involved in the life processes of all organisms.
منابع مشابه
Andrew Zachary Fire (1959- )
Andrew Zachary Fire is a professor at Stanford University [5] and Nobel Laureate. Fire worked at the Carnegie Institution of Washington?s Department of Embryology with colleague Craig Mello, where they discovered that RNA molecules could be used to turn off or knock out the expression of genes [6]. Fire and Mello called the process RNA interference [7] (RNAi), and won the Nobel Prize in Physiol...
متن کاملRNA Interference: Big Applause for Silencing in Stockholm
Eight years ago, Craig Mello, Andrew Fire, and their coworkers provided the first demonstration that double-stranded RNA (dsRNA) triggers the gene-silencing technique that we now call RNA interference (RNAi). For this landmark discovery, Mello and Fire are honored with this year's Nobel Prize in Physiology or Medicine.
متن کاملCraig C. Mello (1960- )
Craig C. Mello is an American developmental biologist and Nobel Laureate, who helped discover RNA interference [4] (RNAi). Along with his colleague Andrew Fire [5], he developed gene knockouts using RNAi. In 2006 Mello won the Nobel Prize in Physiology or Medicine [6] for his contribution to the discovery of RNAi. Mello also contributed to developmental biology, focusing on gene regulation [7],...
متن کاملEvaluation of a Kernel Function for Recognizing microRNAs
MicroRNAs were recently discovered, in 1993, when it was first reported that a small RNA in Caenorhabditis elegans, called lin-4, was responsible for regulating the expression of the lin-14 gene through direct interaction with its messenger RNA [8, 13]. A few years later, Andrew Z. Fire and Craig C. Mello published a paper in Nature [3] describing how tiny snippets of RNA can destroy the gene’s...
متن کاملRibonucleic acid interference: the relevance of molecular targeting and therapeutics to neurosurgical practice.
In October 2006, Andrew Z. Fire (Stanford University School of Medicine) and Craig C. Mello (University of Massachusetts Medical School) were awarded the Nobel Prize in Physiology or Medicine 2006 for their discovery of RNA interference (RNAi)—gene silencing by doublestranded DNA (http://nobelprize.org/). We have compiled an overview of this new technology, addressing the basic concepts of ribo...
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تاریخ انتشار 2007